1H-Pyrazole-4-carbonyl chloride, 5-chloro-1-methyl- (9CI)
5-chloro-1-methyl-1H-pyrazole-4-carbonyl chloride
CAS: 110763-09-2
Molecular Formula: C5H4Cl2N2O
1H-Pyrazole-4-carbonyl chloride, 5-chloro-1-methyl- (9CI) - Names and Identifiers
1H-Pyrazole-4-carbonyl chloride, 5-chloro-1-methyl- (9CI) - Physico-chemical Properties
| Molecular Formula | C5H4Cl2N2O |
| Molar Mass | 179 |
| Density | 1.55±0.1 g/cm3(Predicted) |
| Melting Point | 50 °C |
| Boling Point | 81-85 °C(Press: 0.1-0.2 Torr) |
| Flash Point | 108.3°C |
| Vapor Presure | 0.0163mmHg at 25°C |
| pKa | -1.92±0.10(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | 1.611 |
1H-Pyrazole-4-carbonyl chloride, 5-chloro-1-methyl- (9CI) - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 3261 |
| Hazard Note | Corrosive |
1H-Pyrazole-4-carbonyl chloride, 5-chloro-1-methyl- (9CI) - Introduction
5-Chloro-1-methyl-1H-pyrazole-4-carbonyl chloride, also known as chloride, is an organic compound. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: 5-Chloro-1-methyl-1H-pyrazole-4-carbonyl chloride is white crystal or crystalline powder.
-Molecular formula: C5H5Cl2N3O
-Molecular weight: 189.02g/mol
-melting point: 84-88 ℃
-Boiling point: 258 ℃
-Density: 1.44g/cm3
-Solubility: Soluble in organic solvents such as chloroform, ethanol and dichloromethane.
Use:
-5-Chloro-1-methyl-1H-pyrazole-4-carbonyl chloride is commonly used as an intermediate in organic synthesis and can be acylated during the synthesis.
-It can be used to prepare biologically active molecules, such as drugs and pesticides.
Preparation Method:
A common preparation method is obtained by reacting 5-chloro-1-methyl-1H-pyrazole-4-carbamide with heated silicon chloride. Specific steps are as follows:
1. Under an inert atmosphere, 5-chloro-1-methyl-1H-pyrazole-4-carbamide and a drying agent are added to an organic solvent, and the mixture is stirred.
2. Slowly add silicon chloride dropwise to the reaction mixture while controlling the reaction temperature between -10 and 0°C.
3. After reacting for several hours, the reaction mixture is neutralized with water or an acidic solution.
4. the waste product is frozen and purified by crystallization to obtain the target product.
Safety Information:
-5-Chloro-1-methyl-1H-pyrazole-4-carbonyl chloride is an organic compound with certain toxicity and should be handled with care.
-During operation, appropriate protective equipment should be worn, such as laboratory gloves and protective glasses.
-In case of accidental inhalation or contact with skin and eyes, rinse immediately with plenty of water and seek medical help.
-Store in a dry, well-ventilated place away from heat and flame.
Nature:
-Appearance: 5-Chloro-1-methyl-1H-pyrazole-4-carbonyl chloride is white crystal or crystalline powder.
-Molecular formula: C5H5Cl2N3O
-Molecular weight: 189.02g/mol
-melting point: 84-88 ℃
-Boiling point: 258 ℃
-Density: 1.44g/cm3
-Solubility: Soluble in organic solvents such as chloroform, ethanol and dichloromethane.
Use:
-5-Chloro-1-methyl-1H-pyrazole-4-carbonyl chloride is commonly used as an intermediate in organic synthesis and can be acylated during the synthesis.
-It can be used to prepare biologically active molecules, such as drugs and pesticides.
Preparation Method:
A common preparation method is obtained by reacting 5-chloro-1-methyl-1H-pyrazole-4-carbamide with heated silicon chloride. Specific steps are as follows:
1. Under an inert atmosphere, 5-chloro-1-methyl-1H-pyrazole-4-carbamide and a drying agent are added to an organic solvent, and the mixture is stirred.
2. Slowly add silicon chloride dropwise to the reaction mixture while controlling the reaction temperature between -10 and 0°C.
3. After reacting for several hours, the reaction mixture is neutralized with water or an acidic solution.
4. the waste product is frozen and purified by crystallization to obtain the target product.
Safety Information:
-5-Chloro-1-methyl-1H-pyrazole-4-carbonyl chloride is an organic compound with certain toxicity and should be handled with care.
-During operation, appropriate protective equipment should be worn, such as laboratory gloves and protective glasses.
-In case of accidental inhalation or contact with skin and eyes, rinse immediately with plenty of water and seek medical help.
-Store in a dry, well-ventilated place away from heat and flame.
Last Update：2024-04-09 15:17:50
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CAS: 110763-09-2
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CAS: 110763-09-2
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Mobile: 18021002903
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